Modeling the Quantitative Specificity of DNA-Binding Proteins from Example Binding Sites

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Modeling the Quantitative Specificity of DNA-Binding Proteins from Example Binding Sites

BACKGROUND The binding of transcription factors to their respective DNA sites is a key component of every regulatory network. Predictions of transcription factor binding sites are usually based on models for transcription factor specificity. These models, in turn, are often based on examples of known binding sites. METHODOLOGY/PRINCIPAL FINDINGS Collections of binding sites are obtained in si...

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ژورنال

عنوان ژورنال: PLoS ONE

سال: 2009

ISSN: 1932-6203

DOI: 10.1371/journal.pone.0006736